TOR and Apoptosis
The mTOR pathway is one of several intracellular signaling pathways important in regulating the cell cycle. It is directly related to proliferation, cancer, and longevity. It is also target of Rapamycin- a chemical known to modulate longevity in invertebrate organisms.
Telomeres are distinctive structures found at the ends of our chromosomes. In most species they shorten with every cell division, they play a significant role in the aging process.
Emerging evidence suggests that an aberrant DNA damage response and deficient DNA repair are strongly associated with cancer and aging.
Gene therapy is probably the most promising method that will enable us to change our genome (or the regulation of its expression) permanently. So it is very important to have the method mastered by the time the key variables of aging are deciphered and reversable.