Understanding and Improving our Genetic Inheritance

The First Five Years: Fiscal Years 2018-2022

The Human Immortality Initiative is a worldwide research effort that has the goal of analyzing and reversing the mechanisms of human aging. In addition to determining the genes responsible for aging, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the functioning of the human genome. The information generated by the human immortality project is expected to be a great source book for biomedical science in the 21st century and will be of immense benefit to the field of medicine. It will help us to understand and eventually treat the condition of aging, not to mention spare millions of people years of suffering under age-related-diseases.

A centrally coordinated project focused on specific objectives is believed to be the most efficient and least expensive way of obtaining these informations. In the course of the project much new technology will be developed that will facilitate biomedical and a broad range of biological research, bring down the cost of many experiments, and find application in numerous other fields. The basic data produced will be collected in a databases that will make the information readily accessible in convenient form to all who need it.

In order to achieve the scientific goals set out in this report, a number of administrative measures will be put in place. In addition, a newsletter, an online communication platform and a comprehensive administrative database will be set up to facilitate the communication and tracking of progress.

Research centers will be established to promote the collaboration of investigators from diverse disciplines on major tasks of the biological immortality program. We already have established relations with several organizations of interest worldwide.
The centers will become hubs for collaboration with investigators at other locations and with industrial organizations that want to develop applications of the research results, thereby creating networks of interrelated projects.

Meetings and workshops will be organized to bring together investigators with common research objectives and to encourage collaboration, exchange of materials and use of common starting materials or protocols wherever these are appropriate. It is expected that research groups will connect around particular model organisms or around specific cellular pathways.

HIRI (Human Immortality Research Institute) will expand synergistic working relationships and will also interact closely with other interested agencies, as well as with age combatting programs in other countries as they get organized. Close ties with industry and with the medical community have been established, and will continue to be encouraged, to ensure efficient technology transfer. The private sector shall be involved in this project at all levels from participation in the advisory committees to receipt of grants and contracts.

The overall budget needs for the effort are still estimated, for full efficiency and an approximate completion date of 2038-2050, about $300 million per year are required. Fiscal years 2016 to 2018 are a period for getting organized and getting research under way.
The five-year goals that have been specified in this plan are for the period FY 2018 through FY 2022 and assume the program will rapidly reach the level of funding specified above. A more limited budget will not influence the ambitions taken, but delay the date of completion.


Scientific Goals:

In addition to the long-term objectives of the HIP, this plan sets out specific scientific goals to be achieved in the first five years together with the rationale for each goal. Five-year goals have been identified for the following areas that together cover the HIP:

Determining & Mapping the genes correlated to aging in the Human Genome
Determining & Mapping the genes correlated to aging in the Genomes of Model Organisms
Technology Development
Data Collection and Distribution
Ethical and Legal Considerations
Research Training
Technology Transfer

The specific goals will be reviewed annually and updated as further advances in the underlying technology occur.